Neurodegenerative Disorder

New Discoveries on Neurodegenerative Disorder Strong evidence has emerged to implicate disturbed mitochondrial fusion and fission as central pathological components underpinning a number of neurodegenerative disorders. Imbalances in mitochondrial fusion and fission affects respiratory chain function, mitochondrial quality control (mitophagy), and programmed cell death. The same cellular processes are also implicated in more-common complex neurodegenerative disorders, such as Alzheimer disease and Parkinson disease. This indicates a common pathological thread and a close relationship among mitochondrial structure, function and localization. (Nature Reviews Neurology, 2015) A mitochondrial fission arrest phenotype may cause elongated interconnected organelles, "mitochondria-on-a-string" (MOAS). Findings suggest that MOAS formation may occur at the final stages of fission process and was not associated with altered translocation of activated dynamin related protein 1 (Drp1) to mitochondria but with reduced GTPase activity. The findings on this research brings new attention to the major role of mitochondrial dynamics in regulating neuronal survival. (Scientific Reports, 2016) Mutations in Parkin and PINK1 cause an inherited early-onset form of Parkinson's disease. The two proteins function together in a mitochondrial quality control pathway. Here, a binding switch between phospho-ubiquitin (pUb) and the ubiquitin-like domain (Ubl) of Parkin was found to play a key role in the release of auto-inhibited ubiquitin ligase activity of Parkin. (The EMBO J, 2015) Neurodegenerative Disorders Alzheimer's Disease Abs Huntington's Disease Abs Parkinson's Disease Abs Mitochondria Implicated Neurodegenerative Disorder Pathways (Click to see your products of interest) Eight Product Categories and 1000+ Products 250 Monoclonal Antibodies 397 Polyclonal Antibodies 35 Antibody Pairs 201 Recombinant Proteins 8 ELISA and Assay Kits 189 RNAi 9 FISH Probes 100 Cell Transient Overexpression Lysates Featured Products IGH/BCL2 DY Translocation FISH Probe FT0011 Fluorescent In Situ Hybridization of human cholangiocarcinoma (FFPE) with IGH/BCL2 DY Translocation FISH Probe (Cat # FT0011). IGH (FITC) BCL2 (Texas Red) PARK2 monoclonal antibody (M01), clone 1H4 H00005071-M01 Immunofluorescence of HeLa Cells with PARK2 monoclonal antibody (Cat # H00005071-M01) at 10 ug/mL. BCL2L1 & BAX Protein Protein Interaction Antibody Pair DI0068 Proximity Ligation Assay of HeLa cells with Anti-BCL2L1 rabbit purified polyclonal antibody (1:1200) and anti-BAX mouse monoclonal antibody (1:50). DAPI (blue) References Florence Burté, et.al. (2015). Nature Review Neurology. DOI: 10.1038/nrneurol.2014.228 Liang Zhang, et. al. (2016) Nature Scientific Reports, DOI: 10.1038/srep18725 Véronique Sauvé, et. al. (2015) The EMBO Journal. DOI: 10.15252/embj.201592237 New Products   200 New Monoclonal antibodies for IHC staining to accelerate your work with precision and accuracy