New Discoveries on Bioactive Kinases
- MET receptor tyrosine kinase is regulated by suppresor of cytokine signaling 1 (SOCS1) to attenuate oncogenic MET signaling in hepatocellular carcinoma (HCC) and other cancers. MET inhibitors may be useful in treating HCC patients. (Oncogen,2015)
- EGFR tyrosine kinase inhibitors triggers innate drug resistance through the inhibition of Akt activity and inactivation of Ets-1 to enhance NSCLC cell survival . (PNAS,2015)
- Phosphorylation of Ser293 on α-subunit of pyruvate dehydrogenase complex by PDK3 causes meiotic spindle morphology disruption, chromosome dis-alignment and ATP level reduction in oocyte maturation. (Molecular and Cellular Endocrinology,2015)
Ten Kinase Categories and 394 Products
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Crosstalk Between Kinases and Apoptotic Proteases in Cancer
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This figure has been adapted and altered from López-Otín, C. & Hunter, T., (Nature Revews Cancer,2015).
| Featured Products |
BMPR2 (Human) Recombinant Protein
P5499 |
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The activity was determined by ELISA. The enzyme was incubated with biotinylated substrate protein. After kinase reaction was stopped by EDTA, the reaction solution was transferred into streptavidin- coated plate. Phosphorylation was detected by anti-phospho antibody and HRP-labeled anti-rabbit IgG.
Substrate: ALK4 inactive mutant.
ATP: 100 uM. |
IRAK4 (Human) Recombinant Protein
P5566 |
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The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorescence-labeled substrate and Mg(or Mn)/ATP. The phosphorylated and unphosphorylated substrates were separated and detected by LabChip 3000. Substrate: IRAK1 peptide.
ATP: 1000 uM |
RET (M918T) (Human) Recombinant Protein
P5631 |
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The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorescence-labeled substrate and Mg(or Mn)/ATP. The phosphorylated and unphosphorylated substrates were separated and detected by LabChip 3000. Substrate: CSK peptide. ATP: 100 uM. |
| References |
Gui, Y., et. al. (2015). Oncogene. DOI:10.1038/onc.2015.20
Phuchareon, J., et.al. (2015). PNAS. DOI:10.1073/pnas.1510733112
Couderc, C., et.al. (2015). Molecular and Cellular Endocrinology.
DOI:10.1016/j.mce.2014.09.006
López-Otín, C. & Hunter, T. (2015). Nature Reveiws Cancer. DOI:10.1038/nrc2823 |
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