New Discoveries on Ubiquitylation
- Elongation of ubiquitin chain, regardless of the linkage, can form polyubiquitin fibrils to initiate autophagy pathway. Incapacity of autophagy can cause cytotoxic accumulation of ubiquitin-positive aggregates leading to neurodegenerative diseases. (Nature communication,2015)
- Highly expressed in human breast and lung cancers, a new deubiquitinating enzyme, USP36, was identified to regulate c-Myc oncoprotein stability in nucleolus. (PNAS,2015)
- Itch, an E3 HECT ubiquitin ligase, inhibits MAPK p38α activation through ubiquitylation can be exploited therapeutically to prevent chronic skin inflammation. (Science,2015)
Tumor Related Misregulated Proteins in Ubiquitin Modification
(Click to see your products of interest) |
| Tumor Type |
Deregulated Protein |
Substrate |
Modification |
| Non-Small-Cell Lung Cancer |
MDM2 (39) |
p53/TP53 (151) |
Polyubiquitylation |
| HAUSP/USP7 (8) |
MDM2(39)
p53/TP53 (151) |
De-ubiquitylation |
| Renal Cell Carcinoma |
VHL (16) |
HIF/HIF1/HIF1α (23) |
De-ubiquitylation |
| Colorectal Cancer |
APC (69) |
Cyclin B (31)
Securin |
Polyubiquitylation |
| Lymphoma |
KITLG/SCF (25) |
CDKN1B/p27 (51) |
Polyubiquitylation |
| Fanconi Anaemia-Related Cancer |
ATAD3A/FANCL (9) |
FANCD2 (9) |
Monoubiquitylation |
| MALT Lymphomas |
IAP2 |
BCL10 (15) |
Polyubiquitylation |
| Lymphoma, AML, Gastric Carcinoma |
CBL (33) |
RTKs |
Multiple Monoubiquitylation |
| Cervical Cancer |
UBE3A/E6-AP (11) |
p53/TP53 (151) |
Polyubiquitylation |
| Breast Cancer |
BRCA1 (75) |
Unknown |
Unknown |
| CBL (33) |
EGFR (117) |
De-ubiquitylation |
| Ovarian Cancer |
F-box protein |
Cyclin E/CCNE1 (43) |
De-ubiquitylation |
| ( ) Number of Products Provided by Abnova |
Tumor Related Misregulated Proteins in Ubiquitin Modification
(Click to see your products of interest) |
| Eight Product Categories and 1485 Products |
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| Newly Cited Products |
FBXW7 monoclonal antibody (M02), clone 3D1
H00055294-M02
Yumimoto, K., et al. determined expression of FBXW7, the F-box protein of SCF ubiquitin ligase, can suppress cancer metastasis in either non-cell-autonomous or cell-autonomous manner. Abnova’s FBXW7 monoclonal antibody was used in this study to perform immunocytochemical staining on breast tissues. (JCI, 2015) |
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Immunohistochemistry staining of formalin-fixed paraffin-embedded human lung using FBXW7 monoclonal antibody (3ug/ml). |
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Western Blot detection against FBXW7 partial recombinant protein with GST tag (37.73KDa). |
CCNE1/CEN19p FISH Probe
FG0013
Abnova’s FG0013 CCNE1/CEN19p FISH Probe was recently used by Noske, A., et.al. to evaluate CCNE 1 copy number in the investigation of Cyclin E and URI gene amplification as well as protein expression in different epithelial ovarian cancer subtypes. (Experiment and Molecular Pathology, 2015) |
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Normal human lymphocyte stained with the CCNE1/CEN19p dual color FISH probe at interphase nucleus. |
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Human ovary cancer (FFPE) stained with CCNE1/CEN19p FISH Probe. Human ovary cancer showed no CCNE1 gene amplification. |
| References |
Morimoto, D., et.al. (2015). Nature communications. DOI: 10.1038/ncomms7116
Sun, X.-X., et.al. (2015). PNAS. DOI: 10.1073/pnas.1411713112
Theivanthiran, B., et.al. (2015). Science. DOI: 10.1126/scisignal.2005903
Yumimoto, K., et.al. (2015) JCI. DOI: 10.172/JCI78782
Noske, A., et.al. (2015). Experiment and Molecular Pathology.
DOI: 10.1016/j.yexmp.2014.12.004 |
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