New Discoveries on Ubiquitylation
- Elongation of ubiquitin chain, regardless of the linkage, can form polyubiquitin fibrils to initiate autophagy pathway. Incapacity of autophagy can cause cytotoxic accumulation of ubiquitin-positive aggregates leading to neurodegenerative diseases. (Nature communication,2015)
- Highly expressed in human breast and lung cancers, a new deubiquitinating enzyme, USP36, was identified to regulate c-Myc oncoprotein stability in nucleolus. (PNAS,2015)
- Itch, an E3 HECT ubiquitin ligase, inhibits MAPK p38α activation through ubiquitylation can be exploited therapeutically to prevent chronic skin inflammation. (Science,2015)
Tumor Related Misregulated Proteins in Ubiquitin Modification
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| Tumor Type |
Deregulated Protein |
Substrate |
Modification |
| Non-Small-Cell Lung Cancer |
MDM2 (39) |
p53/TP53 (151) |
Polyubiquitylation |
| HAUSP/USP7 (8) |
MDM2(39)
p53/TP53 (151) |
De-ubiquitylation |
| Renal Cell Carcinoma |
VHL (16) |
HIF/HIF1/HIF1α (23) |
De-ubiquitylation |
| Colorectal Cancer |
APC (69) |
Cyclin B (31)
Securin |
Polyubiquitylation |
| Lymphoma |
KITLG/SCF (25) |
CDKN1B/p27 (51) |
Polyubiquitylation |
| Fanconi Anaemia-Related Cancer |
ATAD3A/FANCL (9) |
FANCD2 (9) |
Monoubiquitylation |
| MALT Lymphomas |
IAP2 |
BCL10 (15) |
Polyubiquitylation |
| Lymphoma, AML, Gastric Carcinoma |
CBL (33) |
RTKs |
Multiple Monoubiquitylation |
| Cervical Cancer |
UBE3A/E6-AP (11) |
p53/TP53 (151) |
Polyubiquitylation |
| Breast Cancer |
BRCA1 (75) |
Unknown |
Unknown |
| CBL (33) |
EGFR (117) |
De-ubiquitylation |
| Ovarian Cancer |
F-box protein |
Cyclin E/CCNE1 (43) |
De-ubiquitylation |
| ( ) Number of Products Provided by Abnova |
Tumor Related Misregulated Proteins in Ubiquitin Modification
(Click to see your products of interest) |
| Eight Product Categories and 1485 Products |
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| Newly Cited Products |
FBXW7 monoclonal antibody (M02), clone 3D1
H00055294-M02
Yumimoto, K., et al. determined expression of FBXW7, the F-box protein of SCF ubiquitin ligase, can suppress cancer metastasis in either non-cell-autonomous or cell-autonomous manner. Abnova’s FBXW7 monoclonal antibody was used in this study to perform immunocytochemical staining on breast tissues. (JCI, 2015) |
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Immunohistochemistry staining of formalin-fixed paraffin-embedded human lung using FBXW7 monoclonal antibody (3ug/ml). |
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Western Blot detection against FBXW7 partial recombinant protein with GST tag (37.73KDa). |
CCNE1/CEN19p FISH Probe
FG0013
Abnova’s FG0013 CCNE1/CEN19p FISH Probe was recently used by Noske, A., et.al. to evaluate CCNE 1 copy number in the investigation of Cyclin E and URI gene amplification as well as protein expression in different epithelial ovarian cancer subtypes. (Experiment and Molecular Pathology, 2015) |
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Normal human lymphocyte stained with the CCNE1/CEN19p dual color FISH probe at interphase nucleus. |
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Human ovary cancer (FFPE) stained with CCNE1/CEN19p FISH Probe. Human ovary cancer showed no CCNE1 gene amplification. |
| References |
Morimoto, D., et.al. (2015). Nature communications. DOI: 10.1038/ncomms7116
Sun, X.-X., et.al. (2015). PNAS. DOI: 10.1073/pnas.1411713112
Theivanthiran, B., et.al. (2015). Science. DOI: 10.1126/scisignal.2005903
Yumimoto, K., et.al. (2015) JCI. DOI: 10.172/JCI78782
Noske, A., et.al. (2015). Experiment and Molecular Pathology.
DOI: 10.1016/j.yexmp.2014.12.004 |
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