New Discoveries on Cytoskeletons
- Self-organization of actin cytoskeleton, the dynamic of radial fibers-transverse fibers system, takes crucial role in developing the left-right asymmetry in tissues and embryos. (Nature Cell Biology,2015)
- Apical and basolateral spectrin cytoskeletons, potential mechano-sensors, regulate Hippo signaling pathway in response to human epithelial cell density. (EMBO,2015)
- Cytoskeleton-associated proteins, CRMP2/DPYSL2, TPM2, TCP1ε and 14.3.3γ, can be potential biomarkers for small-intestinal neuroendocrine tumors invasion. (Molecular and Cellular Endocrinology,2015)
Cytoskeleton Compositions
(Click to see your products of interest) |
Proteins Involved in Cytoskeletons
(Click to see your products of interest) |
| Actin Polymerization |
| Protein |
Function/Activity |
| Cofilin |
Dissociation from (-) end |
| Severin |
Severing, capping (+) end, control of length of actin filaments; essential for branch formation |
| Gelsolin |
Severing, capping (+) end, control of length of actin filaments; essential for branch formation |
| CapZ capping protein |
Capping (+) end, stabilize F-actin prevent disassembly during muscle contraction |
| Tropomodulin |
Capping (+) end, stabilize F-actin prevent disassembly during muscle contraction |
| ARPC 2/3 |
Capping (-) end, side binding and nucleation |
| Classes of Intermediate Filaments |
| Protein |
Function/Activity |
| I. Acidic cytokeratins |
Mechanical strength |
| II. Basic cytokeratins |
Mechanical strength |
III. Vimentin
III. Desmin
III. GFAP |
Maintenance of cell shape
Structural support for contractile machinery
Maintenance of cell shape |
IV. Neurofilament
(NEFL,NEFM,NEFH) |
Axon strength; Determines axon size |
V. Nuclear Lamins
(Lamin A, Lamin B) |
Form nuclear scaffold and shape the nucleus |
| VI. Nestin |
Unknown |
| Modulation of Microtubule Dynamics |
| Protein |
Function |
| MAP1 |
Assembles and stabilizes microtubules |
| MAP2 |
Assembles and cross-links microtubules to one another and intermediate filaments |
| MAP4 |
Stabilizes microtubules |
| MAPT |
Assembles and stabilizes and cross-links microtubules |
| RSN/CLIP1 |
Cross-links microtubules to chromosomes and endosomes |
| Katanin |
Microtubule severing |
| STMN1/OP18 |
Binds to tubulin dimers |
| Eight Product Categories and 2100+ Products |
|
|
|
| References |
Tee, Y.H., et. al (2015). Nature Cell Biology. DOI: 10.1038/ncb3137
Fletcher, G.C., et.al.(2015). EMBO Journal. DOI 10.15252/embj.201489642
Couderc, C., et.al. (2015). Molecular and Cellular Endocrinology. DOI:10.1016/j.mce.2014.09.006 |
|
