Abnova August E-Newsletter
New Discoveries on Lysosomal Regulations Related Research
- A mechanism in phagocytosis involving TFEB-dependent Fcγ-receptor activation was found to enhance lysosomal degradation. The results of this study suggest that phagosomes and lysosomes are capable of bi-directional signaling. (Cell Current Biology, 2016)
- Motility is crucial for lysosomes to traffic towards cargo-carrying vesicles for the degradation of biomacromolecules. Here, the release of Ca2+ through lysosomal Ca2+ channel TRPML1 was found to regulate lysosome motility, positioning and tubulation. (Nature Cell Biology, 2016)
- Results of this study unveiled a lysosomal response to the arrival of autophagosomal cargo in which OCRL plays a key role. Depleting or inhibiting OCRL leads to an accumulation of lysosomal PtdIns(4,5)P2, an inhibitor of the calcium channel mucolipin-1 that controls autophagosome–lysosome fusion. (Nature Cell Biology, 2016)
Lysosomal Membrane Proteins and Diseases
| Gene Name |
Gene ID |
Gene Mutation Related Diseases |
| CLCN7 |
1186 |
Malignant infantile osteopetrosis |
| CLN3 |
1201 |
Juvenile neuronal ceroid lipofuscinosis |
| CTNS |
1497 |
Cystinosis |
| HGSNAT |
138050 |
Mucopolysaccharidosis type IIIC |
| LAMP2 |
3920 |
Danon disease |
| LMBRD1 |
55788 |
Cobalamin F-type disease |
| MCOLN1 |
57192 |
Mucolipidosis type IV |
| MFSD8 |
256471 |
Late infantile neuronal ceroid lipofuscinosis |
| NPC1 |
4864 |
Nemann-Pick type C |
| OSTM1 |
28962 |
Malignant infantile osteopetrosis |
| SCARB2 |
950 |
Action myoclonus-renal failure syndrome |
| SLC17A5 |
26503 |
Salla disease |
Lysosomal Regulations
(Click to see your products of interest) |
|
|
|
| Eight Product Categories and 200+ Products |
|
|
|
Immunofluorescence staining of human primary fibroblasts with CD63 monoclonal antibody, clone MEM-259 (Cat # MAB6493, green) after co-incubation of living cells with human Transferrin-Dyomics 547 (red) . Cell nuclei stained with DAPI (blue).
ATP6V1A monoclonal antibody (M02), clone 4F5
H00000523-M02
Immunohistochemistry staining of formalin-fixed paraffin-embedded human placenta with ATP6V1A monoclonal antibody (M02), clone 4F5 (Cat # H00000523-M02) at 3 ug/mL.
LAMP2/CENXp FISH Probe
FG0059
Fluorescent in situ hybridization of formalin-fixed paraffin-embedded human colon cancer (FFPE) with LAMP2/CENXp FISH Probe. (Cat # FG0059).
LAMP2 (Texas Red)
CENXp (FITC)
| References |
Matthew A. Gray, et. al. (2016). Cell Current Biology. DOI: 10.1016/j.cub.2016.05.070
Xinran Li, et. al. (2016) Nature Cell Biology, DOI: 10.1038/ncb3324
Maria Giovanna De Leo, et. al. (2016) Nature Cell Biology. DOI: 10.1038/ncb3386 |
