Diabetes Research

New Discoveries on Diabetes Leptin was found with the capability of suppressing diabetic hyperglucagonemia through two physiologic pathways, prevention of potentially toxic lipids accumulation and unrecognization of paracrine interactions between α and β cells. (Cell Metabolism, 2015) As β cell failure is one of the major defects in type 2 diabetes mellitus, locally produced apoCIII was identified as an important diabetogenic factor involved in impairment of β cell function. The evidence may also suggest that apoCIII is potentially a novel target for the treatment of type 2 diabetes mellitus. (PNAS, 2015) Neutrophils isolated from type 1 and type 2 diabetic humans and mice were found to produce extracellular traps (NETs, process termed NETosis), which impaired wound healing particularly in diabetes. The evidence supported that inhibiting NETosis or cleaving NETs might improve wound healing and reduce NET-driven chronic inflammation in diabetes. (Nature Medicine, 2015) Type I Diabetes Pathway (Click to see your products of interest) Human/Mouse

Kanehisa Laboratories. (2010, May 23). This figure has been adapted and altered from KEGG.

Type II Diabetes Pathway (Click to see your products of interest) Human/Mouse

Kanehisa Laboratories. (2015, Feb 13). This figure has been adapted and altered from KEGG.

Eight Product Categories and 1800+ Products
618 Monoclonal Antibodies 484 Polyclonal Antibodies 191 Antibody Pairs 224 Recombinant Proteins	92 Assay Kits and ELISA Kits 138 RNAi 14 FISH Probes 81 Cell Transient Overexpression Lysates

Featured Diabetes Related Products
PTPRN2 purified MaxPab mouse polyclonal antibody (B01P) Cat # H00005799-B01P
	Immunohistochemistry staining of formalin-fixed paraffin-embedded human pancreas using PTPRN2 purified MaxPab mouse polyclonal antibody (B01P) (Cat # H00005799-B01P) at 3 ug/mL.
MAPK3 monoclonal antibody (M01), clone 3C9 Cat # H00005595-M01

Immunohistochemistry staining of formalin-fixed paraffin-embedded human placenta using MAPK3 monoclonal antibody (M01), clone 3C9 (Cat # H00005595-M01) at 3 ug/mL.

HLA-A purified MaxPab mouse polyclonal antibody (B01P)
Cat # H00003105-B01P

FACS analysis of negative control 293 cells (Black) and HLA-A expressing 293 cells (Green) using HLA-A purified MaxPab mouse polyclonal antibody (Cat # H00003105-B01P).

PRKCD monoclonal antibody (M06), clone 2E12
Cat # H00005580-M06

Immunofluorescence staining of A-431 cells using PRKCD monoclonal antibody (M06), clone 2E12 (Cat # H00005580-M06) at 10 ug/mL.

IKBKB & CREBBP Protein Protein Interaction Antibody Pair
Cat # DI0278

Proximity Ligation Assay of protein-protein interactions between IKBKB and CREBBP.
HeLa cells were stained with anti-IKBKB rabbit purified polyclonal antibody 1:1200 and anti-CREBBP mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex.

References

Unger, R., et.al. (2015). Cell Metabolism. DOI: 10.1016/j.cmet.2014.10.011 Avall, K., et.al. (2015). PNAS. DOI: 10.1073/pnas.1423849112 Wang, S.-L., et.al. (2015). Nature Medicine. DOI: 10.1038/nm.3887

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140 Phospho Specific Antibodies and Kits Specified for the Study of Phosphorylation 55+ New Antibodies with High Qulity for Flow Cytometry Analysis