RAS Signaling Cancer Research

New Discoveries on RAS Signaling Cancer Research ERK inhibitor alone can suppress the growth of KRAS-mutant pancreatic cancer cell lines and in combination with PI3K inhibition, they can cause synergistic cell death. However, long-term treatment of ERK inhibitor has found to create unexpected senescence and resistence mediated through the degradation of MYC and enhanced basal signaling of PI3K-AKT-mTOR, resepctively. (Cancer Cell,2016) Combination treatment of trametinib and palbociclib on KRAS-mutant colorectal cancer patient derived xenograft models was fround well tolerated and efficacious; it has demonstrated the concept of co-targeting MEK and CDK4/6 can result in anti-tumor activity. This approach may improve the therapeutic outcome for those who are suffering from metastatic colorectal cancer in the future. (Clinical Cancer Research,2016) Through the activation and postive feedback of Ras/Raf/MEK/ERK pathway, Hepatitis C virus (HCV) facilitates the hepatoma cell proliferation. Recently, bromodomain containing 7 (BRD7), a tumor suppressor triggered by Ras/Raf/MEK/ERK signaling, was found to attenuate hepatocellular carcinoma (HCC) development through the negative regulation of the same pathway. Thus, the balance between BRD7 and Ras/Raf/MEK/ERK activity is crucial for the regulation of HCV derived HCC . (Cancer Letters,2016) Ras Signaling for Cancer Growth Suppression (Click to see your products of interest) Eight Product Categories and 1500+ Products 303 Monoclonal Antibodies 638 Polyclonal Antibodies 221 Antibody Pairs 135 Recombinant Proteins 67 ELISA and Assay Kits 85 RNAi 28 FISH Probes 33 Cell Transient Overexpression Lysates Featured Products KRAS monoclonal antibody (M01), clone 3B10-2F2 H00003845-M01 Immunofluorescence staining of HeLa cells with KRAS monoclonal antibody (M01), clone 3B10-2F2 at 10 ug/mL. PDK1 monoclonal antibody, clone 4A11 MAB10380 Immunohistochemsitry analysis of paraffin-embedded human breast cancer tissue using PDK1 monoclonal antibody, clone 4A11 with DAB staining. MTOR monoclonal antibody (M01), clone 2C5 H00002475-M01 Proximity Ligation Analysis of protein-protein interactions between AKT1 and MTOR. HeLa cells were stained with anti-AKT1 rabbit purified polyclonal at 1:1200 and anti-MTOR mouse monoclonal antibody at 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue). References Hayes, T.K., et.al. (2016). Cancer Cell. DOI:10.1016/j.ccell.2015.11.011 Ziemke, E.K., et.al. (2016). Clinical Cancer Research. DOI:10.1158/1078-0432.CCR-15-0829 Zhang, Q., et. al. (2016). Cancer Letters. DOI:10.1016/j.canlet.2015.11.027 New Products   270+ High standard IHC antibodies and 30 ELISA Kits to enhance your research