RNAi Regulations

New Discoveries through RNA interference RNA interference has been developed as methods to evaluate IKK-NF-κB pathway in lung cancer through the influence of IKKα or IKKβ inhibition on NF-κB transcriptional activity and the effects of siRNA-mediated IKK inhibition on cancer proliferation. (Methods in Molecular Biology,2015) High-throughput RNAi kinome screen targeting 720 kinases has identified PDK1 as a factor mediating resistance to CDK4/6 inhibition; thus, it can be a potential drug target in combination with CDK4/6 inhibitor LEE011 to treat ER+ breast cancer. (Cancer Research,2015) Through RNA interference screen, genes, such as TACR1, were identified as factors involved in stress response of mammalian cells and further provides new approaches to reduce the mortality caused by renal ischemia. (Cell Death & Differentiation,2015) RNAi Pathways (Click to see your products of interest) 16 Product Categories 15000+ Products   Antibody Validated Chimera Pre-design Chimera Angiogenesis 2 40 Apoptosis 14 470 Binding 65 2671 Cell Ad/ Junc/ Cytoskeleton 10 535 Cell Cycle 30 704 Cytokine N/A 56 Enzyme 52 793 Membrane 40 2778 Metabolism 13 333 Neurobiology 3 151 Plasma/ Serum 25 860 Signal Transduction 13 623 Stem Cell 10 239 Transcriptions 45 957 Ubiquitin 6 441 Others 45 3200 Featured Products EIF2C2 monoclonal antibody (M01), clone 2E12-1C9 H00027161-M01 Immunohistochemistry staining of formalin fixed paraffin embedded human stomach with EIF2C2 monoclonal antibody (M01), clone 2E12-1C9 at 3 ug/mL. NBR1 Validated Chimera RNAi H00004077-R01V Western blot analysis of NBR1 over-expressed 293 cell line, cotransfected with NBR1 Validated Chimera RNAi. Lane 1. Non-transfected control Lane 2. Transfected with NBR1 validated chimera RNAi Blot was probed with NBR1 monoclonal antibody (M05), clone 5C3 (Cat # H00004077-M05 ). GAPDH was used as loading control. TARDBP Validated Chimera RNAi H00023435-R01V Western blot analysis of TARDBP over-expressed 293 cell line, cotransfected with TARDBP Validated Chimera RNAi. Lane 1. Non-transfected control Lane 2. Transfected with TARDBP validated chimera RNAi Blot was probed with TARDBP monoclonal antibody (M01), clone 2E2-D3 (Cat # H00023435-M01 ). GAPDH was used as loading control. References Bassères, D.S., et.al. (2015). Methods in Molecular Biology. DOI:10.1007/978-1-4939-2422-6_27 Jansen, V.M., et.al. (2015). Cancer Research. DOI:10.1158/1538-7445.AM2015-2844 Zynda, E.R.., et. al. (2015). Cell Death & Differentiation. DOI:10.1038/cdd.2015.128 New Products   High standard IHC antibodies, Rabbit monoclonal antibodies and FISH Probes to fullfill your needs