Exosome Biomarkers

New Discoveries on Exosome Related Research Dendritic cell-derived exosomes (Dex), with surface expression of MHC-peptide complexes, are able to interact with immune cells. Having conducted in advanced malignancies, these nanometer-sized Dexs are able to mediate T and NK cell-based immune response in patients as a feasible and safe immunotherapy for cancer. (The Journal of Clinical Investigation,2016) Tumor derived exosomes (TDEs) carry epithelial mesenchymal transition inducers to invade organ-specific cells and induce organotropic metastasis through stromal remodeling and pre-metastatic niche formation. Pharmacological agents targeting TDE biogenesis, secretion and function, such as heparanase/ syndecan-1 axis, may exert anti-metastatic activity. (Trends in Pharmacological Sciences,2016) Exosome-transmitted IncARSR, by acting as a competing endogenous RNA, can induce sunitinib resistance in renal cancer. IncARSR competitively binds miR-34/miR-449 to facilitate AXL and c-MET expression in renal cell carcinoma and promote sunitinib resistance. Thus, IncARSR may be a potential therapeutic target to restore drug sensitivity. (Cancer Cell,2016) Tumor-derived Exosomes in Tumor Microenvironment (Click to see your products of interest) Eight Product Categories and 770+ Products 314 Monoclonal Antibodies 209 Polyclonal Antibodies 54 Antibody Pairs 76 Recombinant Proteins 43 ELISA and Assay Kits 38 RNAi 6 FISH Probes 31 Cell Transient Overexpression Lysates Featured Products BIRC5 monoclonal antibody (M01), clone 5B10 H00000332-M01 Immunofluorescence staining of HeLa cells with BIRC5 monoclonal antibody (M01), clone 5B10 at the concentration of 10 ug/mL. HSP90AB1 monoclonal antibody, clone 5G4 MAB10686 Immunofluorescence staining of HeLa cells using HSP90AB1 monoclonal antibody, clone 5G4 (green), DRAQ5 fluorescent DNA dye (blue) and Alexa Fluor-555 phalloidin (red). TSG101 monoclonal antibody (M01), clone 5B7 H00007251-M01 Immunohistochemsitry analysis of formalin-fixed paraffin-embedded human kidney tissue using TSG101 monoclonal antibody, clone 5B7 at the concentration of 3 ug/mL. References Pitt, JM., et.al. (2016). The Journal of Clinical Investigation. DOI:10.1172/JCI81137 Syn, N., et.al. (2016). Trends in Pharmacological Sciences. DOI:10.1016/j.tips.2016.04.006 Qu, L., et. al. (2016). Cancer Cell. DOI:10.1016/j.ccell.2016.03.004 New Products   300 High standard Rabbit Polyclonal Antibodies for Immunohistochemsitry Analysis