Hematopoiesis

New Discoveries on Hematopoiesis Hematopoietic stem cell (HSC) is generated from the hemogenic endothelium (HE), where HE and arterial vascular endothelium (VE) was found to represent separate lineages, on the basis of differential expression of CD73 and CD184. (Nature Cell Biology, 2015) HSC regenerative capacity was increased through the inactivation of a histone deacetylase, SIRT7. The interplay of SIRT7 and NRF1 deregulates an unfolded protein response (UPRmt)-mediated metabolic checkpoint which was defined as a reversible contributing factor for HSC aging. (Science, 2015) TET1, the founding member of TET family, was reported as an epigenetic guardian for lymphomagenesis and the TET1 deficiency contributed to predisposed development of B cell malignancy. (Nature Immunology, 2015) Blood Cell Specific Markers (Click to see your products of interest) Cell Type Markers (Human) Markers (Mouse) Hematopoietic Stem Cells Lin-, CD34+, CD38-, FLT3+, THY1+ Lin-, Slamf1 (Cd150)+, Kit+, Casp3 (Sca-1)+ Lin- MS4A1 (CD20), GYPA (CD235a), CD3, NCAM1 (CD56) Ptprc (Cd45ra), Itgam (Cd11b), Cd2, Cd3, Cd4, Cd5, Cd8, Ly6g, Klrb1c, Ly76 Common Lymphoid Progenitor (CLP) MME (CD10)+, CD34+, IL7R (CD127)+ Cd34+, Il7r (Cd127)+ Common Myelold Progenitor (CMP) CD34+, IL3RA (CD123)+, FLT3+ Cd34+, Il3ra (Cd123)+, Casp3 (Sca-1)- Granulocyte/Macrophage Progenitor (GMP) CD34+, CD38+, IL3RA (CD123)+ Cd34+, Cd38+, Il3ra (Cd123)+ Megakaryocyte/Erythroid Progenitor (MEP) CD38+, PTPRC (CD45RA)- Cd38+, Ptprc (Cd45ra)- Megakaryocytes ITGA2B (CD41)+, MT2A (CD42)+, MPL (TPOR)+ Itga2b (Cd41)+, Mt2a (Cd42)+, Mpl (Tpor)+ Monocytes CD14+, CXCR1+, ITGAM (CD11b)+, CD33 (Siglec-3)+ Cd14+, Cxcr1+, Itgam (Cd11b)+, Cd33 (Siglec-3)+ Lymphocytes LY9+, SLAMF7+ Ly9+, Slamf7+ Natural Killer Cells (NK Cells) NCAM1 (CD56)+, CD16+ Ncr1 (Cd335) +, Fcgr3 (CD16)+ B Cells CD19+, MS4A1 (CD20)+ Ptprc (Cd45ra)+, Cd19+, Cd22+ T Cells CD2+, CD3+, CD4+, CD8+ Cd2+, Cd3+, Cd4+, Cd8+ Granulocytes CCR3+, ITGAM (CD11b)+, ANPEP (CD13)+, CD16+, ITGB2 (CD18)+ Ccr3+, Itgam (Cd11b)+, Anpep (Cd13)+, Fcgr3 (Cd16)+, Itgb2 (Cd18)+ Basophils ANPEP (CD13)+, CD164+, IL3RA (CD123)+, LAMP1 (CD107a)+ Anpep+, Cd164+, Il3ra (CD123)+, Lamp1 (Cd107a)+ Neutrophils CD66+, SELL (CD62L)+, MPO+ Ceacam1 (Cd66)+ , Sell+, Mpo+ Eosinophils CD44+, CD69+, EMR1+ Cd44+, Cd69+, Emr1+ Erythrocytes GYPA (CD235a)+, CD59+ Gypa (Cd235a)+, Cd59a+ Dendritic Cells IL3RA (CD123)+, CD80+, CD83+, CD86+, HLA-DRA+ Il3ra (Cd123)+, Cd80+, Cd83+, Cd86+ Macrophages CD14+, CD163+, CD36+, CD68+ Cd14+, Cd163+, Cd36+, Cd68+ Platelets ITGA2B (CD41)+, ITGB3 (CD61)+, PEAR1+ Itga2b (Cd41)+, Itgb3 (Cd61)+, Pear1+ Hematopoiesis (Click to see your products of interest) Eight Product Categories and 500+ Products 224 Monoclonal Antibodies 98 Polyclonal Antibodies 14 Antibody Pairs 109 Recombinant Proteins 69 ELISA Kits and ELISpot Kits 19 RNAi 1 FISH Probe 19 Cell Transient Overexpression Lysates Featured Products IL6 polyclonal antibody PAB27750 Immunohistochemistry staining of paraffin-embedded human lung tissue using IL6 polyclonal antibody (Cat # PAB27750). EPO monoclonal antibody, clone 4F11 MAB10637 Immunofluorescence analysis of GC-7901 cells using EPO monoclonal antibody, clone 4F11 (Cat # MAB10637) (Green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Western blot analysis using EPO monoclonal antibody, clone 4F11 (Cat # MAB10637) against cell lysates. Lane 1: HEK293 Lane 2: EPO-hIgGFc transfected HEK293 References Ditadi A, et.al. (2015). Nature Cell Biology. DOI: 10.1038/ncb3161. Mohrin M, et. al. (2015) Science. DOI: 10.1126/science.1258849. Rasmussen KD, et. al. (2015) Nature Immunology. DOI: 10.1038/ni.3176 New Products   36 Antibodies specific for CD markers in flow cytometry to identify your targets 15 High quality ELISA Kits for the detection and quantification of specific target proteins

Kiss of Death - Ubiquitylation

New Discoveries on Ubiquitylation Elongation of ubiquitin chain, regardless of the linkage, can form polyubiquitin fibrils to initiate autophagy pathway. Incapacity of autophagy can cause cytotoxic accumulation of ubiquitin-positive aggregates leading to neurodegenerative diseases. (Nature communication,2015) Highly expressed in human breast and lung cancers, a new deubiquitinating enzyme, USP36, was identified to regulate c-Myc oncoprotein stability in nucleolus. (PNAS,2015) Itch, an E3 HECT ubiquitin ligase, inhibits MAPK p38α activation through ubiquitylation can be exploited therapeutically to prevent chronic skin inflammation. (Science,2015) Tumor Related Misregulated Proteins in Ubiquitin Modification (Click to see your products of interest) Tumor Type Deregulated Protein Substrate Modification Non-Small-Cell Lung Cancer MDM2 (39) p53/TP53 (151) Polyubiquitylation HAUSP/USP7 (8) MDM2(39) p53/TP53 (151) De-ubiquitylation Renal Cell Carcinoma VHL (16) HIF/HIF1/HIF1α (23) De-ubiquitylation Colorectal Cancer APC (69) Cyclin B (31) Securin Polyubiquitylation Lymphoma KITLG/SCF (25) CDKN1B/p27 (51) Polyubiquitylation Fanconi Anaemia-Related Cancer ATAD3A/FANCL (9) FANCD2 (9) Monoubiquitylation MALT Lymphomas IAP2 BCL10 (15) Polyubiquitylation Lymphoma, AML, Gastric Carcinoma CBL (33) RTKs Multiple Monoubiquitylation Cervical Cancer UBE3A/E6-AP (11) p53/TP53 (151) Polyubiquitylation Breast Cancer BRCA1 (75) Unknown Unknown CBL (33) EGFR (117) De-ubiquitylation Ovarian Cancer F-box protein Cyclin E/CCNE1 (43) De-ubiquitylation ( ) Number of Products Provided by Abnova Tumor Related Misregulated Proteins in Ubiquitin Modification (Click to see your products of interest) Eight Product Categories and 1485 Products 296 Monoclonal Antibodies 529 Polyclonal Antibodies 153 Antibody Pairs 183 Recombinant Proteins 44 Assay Kits and ELISA Kits 180 RNAi 17 FISH Probes 80 Cell Transient Overexpression Lysates Newly Cited Products FBXW7 monoclonal antibody (M02), clone 3D1 H00055294-M02 Yumimoto, K., et al. determined expression of FBXW7, the F-box protein of SCF ubiquitin ligase, can suppress cancer metastasis in either non-cell-autonomous or cell-autonomous manner. Abnova’s FBXW7 monoclonal antibody was used in this study to perform immunocytochemical staining on breast tissues. (JCI, 2015) Immunohistochemistry staining of formalin-fixed paraffin-embedded human lung using FBXW7 monoclonal antibody (3ug/ml). Western Blot detection against FBXW7 partial recombinant protein with GST tag (37.73KDa). CCNE1/CEN19p FISH Probe FG0013 Abnova’s FG0013 CCNE1/CEN19p FISH Probe was recently used by Noske, A., et.al. to evaluate CCNE 1 copy number in the investigation of Cyclin E and URI gene amplification as well as protein expression in different epithelial ovarian cancer subtypes. (Experiment and Molecular Pathology, 2015) Normal human lymphocyte stained with the CCNE1/CEN19p dual color FISH probe at interphase nucleus. Human ovary cancer (FFPE) stained with CCNE1/CEN19p FISH Probe. Human ovary cancer showed no CCNE1 gene amplification. References Morimoto, D., et.al. (2015). Nature communications. DOI: 10.1038/ncomms7116 Sun, X.-X., et.al. (2015). PNAS. DOI: 10.1073/pnas.1411713112 Theivanthiran, B., et.al. (2015). Science. DOI: 10.1126/scisignal.2005903 Yumimoto, K., et.al. (2015) JCI. DOI: 10.172/JCI78782 Noske, A., et.al. (2015). Experiment and Molecular Pathology. DOI: 10.1016/j.yexmp.2014.12.004 New Products   3 FISH Probes for Detecting Gene Amplification in Cancer Cells 49 Pathology Antibodies for High Quality Immunohistochemistry Staining 102 Antibody Pairs for ELISA - Sensitive Detection of Target Proteins

糖尿病研究專用利器：亞諾法最新ELISA及檢測試劑盒！

亞諾法生技(Abnova) 提供了20個最新的ELISA及檢測試劑盒，有利您對於糖尿病及其相關併發症之研究，例如腎功能不全和血管疾病等。這些試劑盒是專門設計用來針對人類或囓齒類動物的脂質過氧化物、糖尿病標記物和糖化蛋白進行定量測量。我們的製造過程擁有卓越的品質控制，可確保您在實驗和臨床研究上的精確性和一致性! 優勢:   ★ 廣泛的目標檢測範圍 ★ 靈敏的分析方法與可重複的結果 ★ 適用於基礎研究和臨床調查 熱門糖尿病試劑盒:   ● ADIPOQ (人類) ELISA Kit ● Adipoq (小鼠) ELISA Kit ● Adipoq (大鼠) ELISA Kit ● C-Peptide ELISA Kit ● Igf1 (小鼠) ELISA Kit ● Igf1 (大鼠) ELISA Kit ● IGFBP3 (人類) ELISA Kit ● Insulin (人類) ELISA Kit ● LEP (人類) ELISA Kit ● RETN (人類) ELISA Kit 更多糖尿病相關研究工具:   ● 單株抗體 ● 多株抗體 ● MaxPab抗體 ● 配對抗體 ● 重組蛋白 ● 螢光原位雜交（FISH）探針 ● ELISA試劑盒 ● 以細胞為基底的ELISA試劑盒 ● 哺乳動物過度表達之細胞溶解物 ● SiRNA/ RNA-DNA嵌合體 最新相關文獻:   Identification and validation co-differentially expressed genes with NAFLD and insulin resistance. Wang XC, Zhan XR, Li XY, Yu JJ and Liu XM. Endocrine. 2014 Apr 4. [Epub ahead of print] 所使用的亞諾法產品: Insulin (Human) ELISA Kit Co-Administration of Metformin and N-Acetyl Cysteine Fails to Improve Clinical Manifestations in PCOS Individual Undergoing ICSI. Cheraghi E, Soleimani Mehranjani M, Shariatzadeh MA, Nasr Esfahani MH, Ebrahimi ZInt J Fertil Steril. 2014 Jul;8(2):119-28. 所使用的亞諾法產品: LEP (Human) ELISA Kit Effects of chenodeoxycholic Acid on the secretion of gut peptides and fibroblast growth factors in healthy humans. Meyer-Gerspach AC, Steinert RE, Keller S, Malarski A, Schulte FH and Beglinger CJ. Clin Endocrinol Metab. 2013 Aug;98(8):3351-8. 所使用的亞諾法產品: C-Peptide ELISA Kit       想進一步瞭解其他含最新文獻之糖尿病相關試劑盒產品嗎? 請見完整列表>>   其他最新產品:   ● 單株抗體 ● MaxPab抗體 ● 配對抗體 ● 重組蛋白 ● 哺乳動物過度表達之細胞溶解物 ● 螢光原位雜交(FISH)探針

亞諾法最新ELISA試劑盒，您最佳研究幫手!

亞諾法生技(Abnova) 為您帶來了179個最新的Sandwich ELISA Kits(三明治酵素連結免疫吸附試劑盒)，這些試劑盒已被廣泛應用到基礎研究和疾病研究，例如氣喘、糖尿病、腎功能不全和血管疾病等。這些高品質的試劑盒是設計用來定量測定來自人類與鼠類等不同生物樣品的135個重要蛋白質標靶，包括其血液、血漿、血清和尿液等。 歡迎參觀我們的官方網站，這裡有豐富完整的ELISA試劑盒產品清單供您選擇喲! ELISA試劑盒的熱門標靶: ● TGFBR2 ● EPO ● PGE2 ● PPIA ● PTH ● Albumin ● Cortisol ● Dopamine ● Free PSA ● Insulin 更多ELISA相關研究工具: ● Antibody Pairs for ELISA ● Cell-Based ELISA Kits ● ELISpot Kits 最新ELISA試劑盒9折優惠 (自即日起至9月26日截止): ● Human Targets ● Mouse Targets ● Rat Targets ● Other Targets 亞諾法的AbVideoTM: ELISA試劑盒相關之視訊教學       Indirect ELISA Sandwich ELISA Competitive ELISA       Sandwich ELISA - Isotype Detection ELISA Substrate Kit - Introduction LEP (Human) Clinical Range ELISA Kit       FSH ELISA Kit HCG ELISA Kit Pork (Pig) ELISA Kit         Total IgG (Human) ELISA Kit Anti-PEG Antibody Pair   最新ELISA相關文獻: Changes in morphology and function of adrenal cortex in mice fed a high-fat diet. Swierczynska MM, Mateska I, Peitzsch M, Bornstein SR, Chavakis T, Eisenhofer G, Lamounier-Zepter V, Eaton SInt J Obes (Lond). 2014 Jun 12. doi: 10.1038/ijo.2014.102. 所使用的亞諾法產品: ACTH (Mouse/Rat) ELISA Kit Biphasic mechanisms of amphetamine action at the dopamine terminal. Siciliano CA, Calipari ES, Ferris MJ, Jones SRJ Neurosci. 2014 Apr 16;34(16):5575-82. doi: 10.1523/JNEUROSCI.4050-13.2014. 所使用的亞諾法產品: Amphetamine ELISA Kit Effects of mild calorie restriction on anxiety and hypothalamic-pituitary-adrenal axis responses to stress in the male rat. Kenny R, Dinan T, Cai G, Spencer SJPhysiol Rep. 2014 Mar 1;2(3):e00265. doi: 10.1002/phy2.265. Print 2014. 所使用的亞諾法產品: Corticosterone ELISA Kit Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BBNature. 2014 Apr 10;508(7495):258-62. doi: 10.1038/nature13198. 所使用的亞諾法產品: Diacetylspermine ELISA Kit Alterations in dopamine system function across the estrous cycle of the MAM rodent model of schizophrenia. Perez SM, Chen L, Lodge DJ.Psychoneuroendocrinology(2014), DOI: 10.1016/j.psyneuen. 2014.05.005 所使用的亞諾法產品: Progesterone ELISA Kit Upregulation of glucose metabolism by NF-kappa B2/p52 mediates enzalutamide resistance. Cui Y, Nadiminty N, Liu C, Lou W, Schwartz CT, Gao ACEndocr Relat Cancer. 2014 May 6;21(3):435-42. doi: 10.1530/ERC-14-0107. Print 2014. 所使用的亞諾法產品: PSA (Human) ELISA Kit