Wnt/β-catenin Signaling Pathway

New Discoveries on Wnt/β-catenin Signaling Pathway PolyADP-ribose polymerase Tankyrase plays a key role in oncogenic Wnt/β-catenin signaling pathway. This study unveils that in addition to facilitating cytosolic β-catenin accumulation, the polymerization of TNKS and TNKS2 sterile alpha motif domains is also essential to drive oncogenic gene transcription. (Molecular Cell, 2016) New mechanism of action for axitinib, a clinically approved tyrosine kinase inhibitor for treating renal cell carcinoma, is demonstrated here. Axitinib is shown to directly target and stabilize SHPRH, an E3 ubiquitin ligase. In doing so, axitinib blocks Wnt/β-catenin signaling pathway by increasing nuclear β-catenin ubiquitination and degradation, and ultimately promotes asymmetric cell division in cancer cells. (PNAS, 2016) New therapeutic aspects in treating chemoresistant cancer are proposed. Due to the common upregulation of O6-methylguanine-DNA methyltransferase (MGMT) in patients developing chemoresistance, this study demonstrates that successful inhibition of Wnt/β-catenin signaling downregulates expression of MGMT and restores chemosensitivity. (Nature Communications, 2015) Wnt/β-catenin Signaling Pathway (Click to see your products of interest) Eight Product Categories and 1700+ Products 428 Monoclonal Antibodies 594 Polyclonal Antibodies 177 Antibody Pairs 236 Recombinant Proteins 46 ELISA and Assay Kits 158 RNAi 35 FISH Probes 70 Cell Transient Overexpression Lysates Featured Products CTNNB1 monoclonal antibody (M02), clone 1C9 H00001499-M02 Immunofluorescence staining of HeLa cells with CTNNB1 monoclonal antibody, clone1C9 (Cat. #H00001499-M02) at 10 ug/ml. WNT5A monoclonal antibody (M04), clone 3A4 H00007474-M04 Immunohistochemistry staining of formalin-fixed paraffin-embedded human placenta with WNT5A monoclonal antibody, clone 3A4 (Cat. # H00007474-M04) at 3 ug/ml. MYC (Orange) FISH Probe FG0099 Fluorescent in situ hybridization of MYC FISH probe in human cell lines (Cat. # FG0099). Corresponding images of hybridization results in a low copy-number MYC expressing HL60S cell line (left) and high copy-number MYC expressing NCiN417 cell line (right). References Laura Mariotti et. al. (2016) Molecular Cell, DOI:10.1016/j.molcel.2016.06.019 Malin Wickström, et. al. (2015) Nature Communications. DOI:10.1038/ncomms9904 Yi Qu, et. al. (2016). PNAS. DOI: 10.1073/pnas.1604520113 New Products   200+ New Mouse Monoclonal Antibodies to empower your research